The joint operation was carried out in Co Cavan yesterday.
Officers remain in the area while they carry out enquiries.
The incident took place over the weekend.
Local Gardaí are appealing to all road users to never drive while under the influence of alcohol or drugs.
The incident took place in Cavan Town on Friday evening.
Gardaí have notably said further updates are expected to follow.
The two men were arrested this morning.
The detection was made on the N2 early yesterday morning.
Police in Co Fermanagh are appealing for any witnesses in relation to this incident to come forward.
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