Emergency powers introduced two years ago to help fight Covid-19 expire at midnight.
They allowed the Health Minister to restrict travel, prevent gatherings and close premises in an effort to slow the spread of the virus.
Most restrictions have now been lifted, however advice remains to wear a mask on public transport and in health settings.
However nurses want a mandate reintroduced to help ease pressure on hospitals.
Consultant in Emergency Medicine, Chris Luke, says the situation is extremely challenging: