A man in his 60s was taken to hospital following a collision on the Knockmany Road in Augher on Friday night.
The collision involving an Audi Q5 and a Scania lorry was reported to police at around 8.40pm.
The injured man, who was the driver of the car, is understood to be in a critical condition in hospital.
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The Knockmany Road remained closed overnight whilst police examined the scene, however the road has since reopened.
Anyone who witnessed the collision or captured dash-cam footage is asked to contact police by calling 101, quoting reference 1876 27/01/23.
